Endothelial Organ-on-Chip Model
Endothelial Organ-on-Chip Model
Revolutionizing Blood Vessel Research

Bi/ond’s innovative Organ-on-Chip technology offers a cutting-edge solution for studying endothelial cells and blood vessels in vitro. The inCHIPit™ platform enables researchers to create realistic and robust blood vessel models using a variety of cell sources, including primary cells (e.g HUVECs), iPSC-derived ECs, cell lines (e.g HMEC-1) and other organ-specific endothelial cells. This flexibility allows researchers like you to select the most appropriate cell type for their specific research question.
Here's how Bi/ond's endothelial Organ-on-Chip system can advance your research

Achieve Full Channel Coverage
The inCHIPit™ platform ensures complete endothelial cell coverage within a single seeding step, enabling the formation of a confluent and functional endothelial monolayer.
Image details: Green = Actin , Blue = DAPI
Study Cell Behavior Under Flow
Image details: Blue = DAPI, Red = VE-cadherin

Assess Barrier Integrity and Transport
Accurately quantify barrier integrity and cellular transport across the endothelial layer, providing valuable insights into blood vessel function and permeability.
Establish Organ-Specific Microenvironments
Vascularize your tissue models, including organoids, tumoroids, and tissue slices, by co-culturing them with the endothelial layer. This creates a more physiologically relevant environment for studying tissue-blood vessel interactions.
Long-Term Culture and Perfusion
The inCHIPit™ platform supports long-term continuous perfusion, supplying nutrients and oxygen to your tissue model and ensuring cell viability over extended periods.


Compared to the standard culture method, the CoC platform shows greater proliferation (EdU staining) and reduced cell death (TUNNEL staining). Furthermore, compared to fresh tissue, little change in cell proliferation was observed in the CoC platform. Altogether the results reveal greater preservation of tumour tissue architecture in the CoC platform compared to the standard culture method. Read more about this research.
Additional applications utilising Bi/ond's technology for endothelial cell studies
Bi/ond’s endothelial Organ-on-Chip technology provides a powerful tool for researchers in various fields, including:
- Drug dosing, discovery and development
- Toxicology
- Disease modeling
- Personalized medicine
Contact us today to learn more about how our endothelial Organ-on-Chip platform can help you achieve your research goals.
Additional information:
- For more information on our solutions visit our product and applications pages and/or access the study from Erasmus MC
- To order our products, or to arrange a Proof of Concept study, please contact our sales team.