Endothelial Organ-on-Chip Model

Revolutionizing Blood Vessel Research

Bi/ond’s innovative Organ-on-Chip technology offers a cutting-edge solution for studying endothelial cells and blood vessels in vitro. The inCHIPit™ platform enables researchers to create realistic and robust blood vessel models using a variety of cell sources, including primary cells (e.g HUVECs), iPSC-derived ECs, cell lines (e.g HMEC-1) and other organ-specific endothelial cells. This flexibility allows researchers like you to select the most appropriate cell type for their specific research question.

Here's how Bi/ond's endothelial Organ-on-Chip system can advance your research

endothelial cells
Achieve Full Channel Coverage


The inCHIPit™ platform ensures complete endothelial cell coverage within a single seeding step, enabling the formation of a confluent and functional endothelial monolayer.

Image details: Green = Actin , Blue = DAPI

Study Cell Behavior Under Flow
The system allows researchers to investigate cell alignment, maturation, and expression profiles under physiological flow conditions, mimicking the in vivo environment of blood vessels.

Image details: Blue = DAPI, Red = VE-cadherin

endothelial flow
Assess Barrier Integrity and Transport

Accurately quantify barrier integrity and cellular transport across the endothelial layer, providing valuable insights into blood vessel function and permeability.

Establish Organ-Specific Microenvironments

Vascularize your tissue models, including organoids, tumoroids, and tissue slices, by co-culturing them with the endothelial layer. This creates a more physiologically relevant environment for studying tissue-blood vessel interactions.

Long-Term Culture and Perfusion

The inCHIPit™ platform supports long-term continuous perfusion, supplying nutrients and oxygen to your tissue model and ensuring cell viability over extended periods.

endothelial long term culture
endothelial perfusion

Compared to the standard culture method, the CoC platform shows greater proliferation (EdU staining) and reduced cell death (TUNNEL staining). Furthermore, compared to fresh tissue, little change in cell proliferation was observed in the CoC platform. Altogether the results reveal greater preservation of tumour tissue architecture in the CoC platform compared to the standard culture method. Read more about this research. 

Additional applications utilising Bi/ond's technology for endothelial cell studies

Bi/ond’s endothelial Organ-on-Chip technology provides a powerful tool for researchers in various fields, including:

  • Drug dosing, discovery and development
  • Toxicology
  • Disease modeling
  • Personalized medicine

Contact us today to learn more about how our endothelial Organ-on-Chip platform can help you achieve your research goals. 

Additional information:

Logo Bi/ond

Bi/ond protects your privacy: when you request a quote, documentation or price options your personal data will be transferred to the Bi/ond team who will be able to contact you directly. See our Privacy Policy for details on the method used to process your data, the purpose and your rights concerning this data. By continuing to use our website you agree to our General Terms of Use.