Applications

Bi/ond platform is versatile, as it is qualified for culturing complex 3D tissues (organoids, ex vivo tissue, spheroids, microtissues) as well as for tissue-tissue interface models

Ex-vivo

– Extend ex-vivo tissues lifetime

– Easy sample loading and unloading

– Collect tissue transudate

– Compatible with chemotherapies

Organoids

– Easily achieved microfluidic culture of organoid tissues- Longitudinal testing made easy with microscope compatible devices

– Perform tests in parallel or in series

– Easily recover your organoids for post-culture
assays

Tissue-Tissue

– Simply seed the cells in the microfluidic channel in a single injection step

– Easily access the cell culture via the open well

– Nourish and stimulate your cell culture with physiologically relevant fluid flows

– Analyse your co-culture with fluorescence and confocal imaging

We are applying BI/OND devices in therapy response using the breast PDX model. BI/OND microfluidics chips guarantee a more controlled condition, which is beneficial for long term tumor tissue slice culture.
Dr. Dik van Gent Assistant Professor, Department of Molecular Genetics at Erasmus Medical Center
“BI/OND’s Organ-on-Chip allowed us to study the effects of dynamic perfusion on midbrain organoids with a wide range of flow rates. The chip’s open well provides easy access for inserting and recovering the organoids
Dr. Nicholas Kurniawan Assistant Professor, Department of Soft Tissue Engineering and Mechanobiology group at Eindhoven University of Technology
We chose BI/OND products to combine vascular flow with stem cell-derived heart tissue such that they are close together as in a real heart. What I like the most is the beautiful design of their products
Prof. Christine Mummery Chair of the Department of Anatomy and Embryology at Leiden University Medical Center
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Biological Assays

1. Morphology 
2. Proliferation
3. Apoptosis
4. Chemotherapy response
5. Long-term culture up to 14 days
6. Outflow exosome analysis
7. Gene expression analysis
8. Next generation mRNA sequencing
9. Immunostaining

1. Morphology 
2. Viability
3. Drug Response
4. Long-term culture up to 1 month
5. Protein expression analysis western blot and Immunostaining

1. Morphology 
2. Viability
3. Co-culture
4. Tissue stretching
5. Muscle cell pacing
6. Analysis of muscle contraction
7. Cell Differentiation
8. Barrier formation assay
Immunostaining

Download Blood-Vessel Brochure

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