The MUSbit™, in combination with the comPLATE™, presents a revolutionary solution for culturing mature, contractile muscle tissue. This system not only offers the capability to study the functioning of (heart) muscle tissue, but also provides a platform for testing the efficacy of new drugs, thanks to the microfluidic channel.
With the innovative open well design, you can pour your cell suspension of muscle cells into the well, watch as they begin to grow, and witness their contractions in real-time. As the cells start to pull on the two pillars, the shift of these pillars can be monitored to determine the force and rate of contraction.
The underlying microfluidic channel can be lined with endothelial cells, mimicking a real 3D blood vessel, providing the muscle tissue with continuous access to essential nutrients and oxygen. Moreover, it also allows for administration of drugs and other substances and subsequent monitoring of any effects on the muscle tissue in the open well.
The built-in electrodes allow for the recreation of a heartbeat.
With the innovative open well design of our chip, you can pour your cell suspension of muscle cells into the well and watch as they begin to grow in between the two pillars.
The underlying microfluidic channel can be lined with endothelial cells, mimicking a real 3D blood vessel, providing the muscle tissue with continuous access to essential nutrients and oxygen. Moreover, the channel also allows for administration of drugs and other substances and subsequent monitoring of any effects on the muscle tissue in the open well.
Applying external electrodes makes it possible to stimulate the contraction of the muscle bundles in between the two pillars. As the muscle bundles start to pull on the pillars, the shift of them can be monitored to determine the force and rate of contraction. This allows for checking any disruption in muscle function before and after treatments.
Our MUSbit™ platform is currently being tested at the Leiden University Medical Center in the Netherlands, with a publication about the results in the works. Get ahead of the curve and take the first step towards a more comprehensive understanding of (heart)muscle function.
Watch as the black and white video showcases a functional muscle bundle, contracting in between the two pillars of the MUSbit™. Witness the tissue contract natively or in response to cardiac stimulants, suppressants, or even cardiotoxic compounds. The results of this work done in collaboration with LUMC Leiden, Netherlands, are currently under embargo awaiting the world to see its exciting results.
That’s not all, take a look at the stunning fluorescent bundle of cardiac muscles grown between the two pillars of the MUSbit™ on this other video. This bundle has been stained for α-Actin (red, marker for cardiac muscle tissue), cardiac troponin (green, marker for myocardial damage), and DAPI (blue, staining cell nuclei).
Work in collaboration with LUMC Leiden, manuscript in preparation.
If you want to discover how we have managed to successfully culture skeletal muscle cells
on our MUSbit™ platform to generate 3D skeletal muscle microtissue, download tis resource now.
Bi/ond protects your privacy: when you request a quote, documentation or price options your personal data will be transferred to the Bi/ond team who will be able to contact you directly. See our Privacy Policy for details on the method used to process your data, the purpose and your rights concerning this data. By continuing to use our website you agree to our General Terms of Use.
Click to download the items.
