comPLATE™

A Simple Smart Well-Plate for Complex 3D Cell Models

cell on a chip

The comPLATE™ is a revolutionary smart well-plate designed to facilitate the cultivation of intricate 3D tissue cultures, seamlessly complementing our inCHIPit™ and MUSbit™ platforms.

Experience effortless control over our inCHIPit ™ and MUSbit ™ with the comPLATE ™ interface. Designed to support the various capabilities of our chips, the comPLATE ™ simplifies and streamlines your research processes.

 

With its intuitive interface and plug-and-play modules, the comPLATE™ simplifies and streamlines your research processes, empowering you to delve deeper into the complexities of 2D and 3D cell cultures, including 3D organoid models, 3D muscle models, and multi organ on a chip studies.

Introducing the ComPLATE™

ComPLATE™ is a smart, compact and reusable well-plate designed to house inCHIPit™ and MUSbit™ for the cultivations of complex tissues. It consists of a black 6-wells bottom plate, a transparent top plate that covers the chip and a white fixation ring.

 

The single flow top plate has an opening on top for pipetting into the chip well and a lid to cover it, as well as two inlets for connecting to a pump.

 

The double flow top plate, on the other hand, has four in- and outlets to which one or more channels of a pump can be connected and no top opening or lid. This versatile system is compatible with different perfusion systems, such as syringe or peristaltic pumps, and can be used with minimal training.

 

It is one plate that has many functionalities thanks to its plug-and-play modules: 

Safety Toxicology
microfluidic flow cell channel

Optimal Closed Environment for Tissue Cultures on Chip

The comPLATE ™ provides an optimal closed environment for tissue cultures on chip. The fixation ring ensures that the chip is securely in place and prevents leakage.

Single or Double Perfusion

The comPLATE ™ supports both single and double perfusion. The single flow top plate has one inlet and one outlet that allows for a flow of media in and out of the microfluidic channel underneath the membrane.

The double flow top plate has two inlets and two outlets, positioned perpendicular to each other. One set of inlets and outlets provides fluid in and out of the microfluidic channel, while the other set feeds in and out of the top well above the membrane.

Mechanical Stimulation

The comPLATE ™ allows for mechanical stimulation of the tissues. The pneumatic system can be used to apply pressure to the top well, which can be used to stretch or deform the cells. This can be used to study the effects of mechanical stress on the cells, such as wound healing or muscle contraction.

Compatibility with Different Microscopes for Imaging

The comPLATE ™ is compatible with different microscopes for imaging. The transparent top plate allows for easy observation of the cells using a variety of imaging techniques, such as brightfield, fluorescence, and confocal microscopy.

Plug-and-Play Modules for Gradual Addition of Functionalities

With its plug-and-play modules, you can gradually add functionalities as you gain experience and expand your requirements. From process analyses (such as cell morphology, viability, medium analysis) to end assays (for instance histology, qPCR, protein analysis, fixate cells, staining) the ComPLATE™ is the ultimate tool for your tissue culture needs.

microfluidic flow channel




Specifications

comPLATE 3D reconstruction from top
ComPLATE ™
Plate length
127.5 mm
Plate width 
85 mm
Diameter one well
40 mm
Distance top opening to chip
16 mm
Working distance for microscopy
2.1 mm 
comPLATE 3D reconstruction
Sketch of comPLATE functioning

Single or double perfusion microfluidics

The ComPLATE™, our compact and reusable interface, supports two different top plates for supplying the culture on our chips with media or other fluidics. These are the single flow top plate and the double flow top plate.


The single flow top plate has one inlet and one outlet that allows for a flow of media in and out of the microfluidic channel underneath the membrane.

The double flow top plate has two inlets and two outlets, positioned perpendicular to each other. One set of inlets and outlets provides fluid in and out of the microfluidic channel, while the other set feeds in and out of the top well above the membrane.


A pneumatic system is a crucial component for establishing a continuous flow of media on our chips in the ComPLATE ™. The chips can be connected to the pneumatic system either independently to the pump or in a series configuration to connect multiple organ systems together. Our team can provide guidance on the compatibility of your existing pump with the desired setup or recommend a pump that is best suited for your needs.

Simple assembly for your 3D cell models

The comPLATE ™ is easy to assemble and use. The chips can be inserted into the bottom plate and the top plate  can be placed over them. The fixation ring can then be used to secure the chips in place. The pneumatic system can be connected to the chips using the provided tubing.

Once the comPLATE ™ is assembled, it can be placed on a microscope stage for imaging. The cells can be observed using a variety of imaging techniques, such as brightfield, fluorescence, and confocal microscopy.

The comPLATE ™ is a versatile and powerful tool for the cultivation of complex 3D tissues, and building your 3D model. It is easy to use and provides a variety of functionalities that can be used to study a wide range of biological processes.

The comPLATE™ is an innovative and easy to use platform in the field of 3D cell cultures, modeling, and microfluidics. Its small footprint (it literally fits on the palm of your hand), its ability to seamlessly integrate with inCHIPit™ and MUSbit™ chips, and its adaptable single and double flow top plates, makes it an indispensable tool for any laboratory looking to push the boundaries of scientific exploration.

The comPLATE™ grows with how your research expands, offering the flexibility and functionality you need to achieve your goals. Make comPLATE™ the cornerstone of your 3D cell culture journey and unlock the potential of your research.

 

Additional Information

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