Discover the versatility of the Bi/ond organ on chip platform with the inCHIPit™ and comPLATE™.
Create a human-derived research model that mirrors the organ of your choice like never before.
Organ on chip technology has revolutionized the field of organoid research, offering a multitude of applications and breakthroughs that expand our understanding of human biology.
As such, human organ on chip technology has emerged as a cornerstone of contemporary biotechnology. The ability to recreate the microenvironment of specific organs with remarkable precision allows scientists to model various organoid types more effectively than ever before. Whether it’s the simulation of a kidney, heart, or liver, the Bi/ond organ on chip platform empowers researchers to delve deep into the intricancies of these vital organs. Including possibilities for multi organ on chip structures.
The versatility of our organ on chip microfluidics plays a pivotal role in facilitating organoid culture. The open well design of the chip allows for easy of access to your organoid, and direct manipulation from the top. Furthermore, thanks to the clear, optically transparent window on the bottom, you have the possibility to do real-time imaging, enhancing the precision of experiments. Additionally, the microfluidic channels can be lined with endothelial cells to replicate the intricate blood vessels in vivo, mimicking a real 3D blood vessel, ensuring that the organoids receive a continuous supply of essential oxygen and nutrients. This is not only conducive to long-term organoid culture but also enables the administration of drugs and other substances directly to the organoid for comprehensive testing.
The Bi/ond organ-on-chip platform has already been adopted by leading researchers to drive organoid-based research forward. Examples like the vascularization of kidney organoids at Erasmus Medical Center illustrate the platform’s practicality and effectiveness in real-world applications. By fostering kidney organoid differentiation and microvascular structure formation, this technology accelerates advancements in kidney development and disease research.
Get closer to uncovering the mysteries of your organoid assays with the Bi/ond organ-on-chip technology!
Here you can find an example of how our technology has been used to advance organoid-based research. Our inCHIPit™ platform, in combination with the comPLATE™, has been utilized by leading researchers in Erasmus Medical Center to vascularize kidney organoids and more. To learn more about how our technology has been put into action, you can read the full paper from Bas‑Cristóbal Menéndez et al. 2022 here.
Kidney organoids derived from human induced pluripotent stem cells (iPSCs) can be a valuable tool to study kidney development and disease, but the lack of vascularization limits long term research.
In this article, the Bi/ond organ on chip system, consisting of the inCHIPit™ 3C with the comPLATE™, was used to culture kidney organoids for 9 days with a continuous flow. Our system supported kidney organoid differentiation and the formation of microvascular structures that fused into perfusable lumens, mimicking normal vascularization.
GFP+ HUVECs seeded in one of the three microfluidic channels beneath the culture chamber were able to migrate through the porous membrane and formed a monolayer in the culturing chamber, as shown in the picture on the left.
The cells survived 9 days of fluidic flow shearing stress and adopted a directionality in concordance with native endothelium, mimicking vasculature in vitro.
Co-culturing of the organoids in the culture chamber and HUVECs in the microfluidic channel led to the establishment of vascular-like structures with open lumens in the organoid tissue, as shown in the picture on the right.
This organ on chip model therefore provides a useful insight into kidney organoid vascularization in vitro and presents a tool for further studies of kidney development and drug testing, both for research purposes and pre-clinical applications.
The Bi/ond organ on chip platform, with its microfluidic capabilities and multi-organ interaction potential, is a groundbreaking technology that redefines the way we conduct organoid research.
From the vascularization of (kidney or other) organoids to drug testing and beyond, this technology opens doors to a myriad of opportunities in both research and pre-clinical applications, bringing us closer to understanding and harnessing the power of human biology.
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